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BN41717R-50ul
50ul
￥1486.00
交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41717R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41717R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
產(chǎn)品描述
| 英文名稱 | GATA3 |
| 中文名稱 | GATA結(jié)合蛋白3抗體 |
| 別 名 | GATA 3; GATA-3; GATA binding factor 3; GATA binding protein 3; HDR; MGC2346; MGC5199; MGC5445; Trans acting T cell specific transcription factor GATA 3; GATA3_HUMAN; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3. |
| 研究領(lǐng)域 | 免疫學 發(fā)育生物學 染色質(zhì)和核信號 干細胞 t-淋巴細胞 鋅指蛋白 表觀遺傳學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Guinea Pig, ) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GATA3:331-443/443 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites. Function: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Subcellular Location: Nucleus. Tissue Specificity: T-cells and endothelial cells. DISEASE: Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome. Similarity: Contains 2 GATA-type zinc fingers. SWISS: P23771 Gene ID: 2625 Database links: Entrez Gene: 2625 Human Entrez Gene: 14462 Mouse Omim: 131320 Human SwissProt: P23771 Human SwissProt: P23772 Mouse Unigene: 524134 Human Unigene: 313866 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GATA-3屬于轉(zhuǎn)錄調(diào)節(jié)性因子，表達在腦組織、胸腺中及其他很多組織中，并調(diào)節(jié)該類T細胞的發(fā)育和功能 |
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